期刊
CATALYSIS LETTERS
卷 149, 期 4, 页码 1057-1066出版社
SPRINGER
DOI: 10.1007/s10562-019-02668-z
关键词
Organocatalyst; Nicotine; 1; 5-Benzodiazepines; Bis-1; 5-benzodiazepines; Water media
资金
- Iranian National Science Foundation (INSF) [94027561]
- Research Council of the University of Isfahan
A new nicotine-based organocatalyst supported on silica nanoparticles (Fe(III)-NicTC@nSiO(2)) was prepared and characterized by different techniques. A series of 1,5-benzodiazepines derivatives were smoothly synthesized via the tandem process, starting from o-phenylenediamine and dimedone (or 1,3-cyclohexanedione), followed by addition of aldehyde in the presence Fe(III)-NicTC@nSiO(2) catalyst in water at room temperature. The Fe(III)-NicTC@nSiO(2) was also applied as an efficient catalyst for the selective synthesis of mono- and bis-1,5-benzodiazepines. Excellent yields and selectivity, short reaction time, mild conditions, and reusability of the catalyst are valuable features of this method.
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