Dietary fiber, glycemic index, glycemic load and renal cell carcinoma risk

Several epidemiological studies have investigated the potential association between dietary fiber, glycemic index (GI) or glycemic load (GL), and renal cell carcinoma (RCC) risk with inconsistent results. The aim of this study was to systematically evaluate this issue with a meta-analysis approach. A comprehensive literature search up to March 2018 was performed in PubMed and Web of Science databases. Summary relative risks (RRs) and 95% confidence intervals (CIs) were estimated with a random-effects model. Twelve studies were finally included in this study (eight for fiber analysis, five for GI and five for GL). A significant positive association was observed between GI and the risk of RCC (summary RR 1.16, 95% CI 1.02-1.32), and no significant heterogeneity was detected among studies (I-2 = 22.8%, P = 0.262). A significant inverse association was found between fiber intake and the risk of RCC (summary RR 0.82, 95% CI 0.72-0.92), and no significant heterogeneity was observed across studies (I-2 = 27.6%, P = 0.218). GL was not significantly associated with RCC risk (summary RR 1.14, 95% CI 0.81-1.60), and significant heterogeneity was found across studies (I-2 = 78.6%, P < 0.001). In conclusion, this systematic review and meta-analysis suggests that dietary GI and fiber may be associated with the risk of RCC. Further large prospective cohort studies are still warranted to confirm our preliminary findings.