期刊
CARBOHYDRATE POLYMERS
卷 205, 期 -, 页码 427-436出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.10.061
关键词
Hydrogel; Pectin; Bioactive glass; Antibacterial; Bone tissue engineering
资金
- Research Foundation Flanders (FWO)
- Ghent University
- FWO [G0A0417 N]
- National Science Centre, Poland [2017/24/T/ST8/00041, 2014/13/B/ST8/02973]
- Foundation for Polish Science (FNP)
The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and < 45 mu m). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. mu CT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.
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