Synthesis of highly stable bacterial cellulosic pocket for drug storage

Inulin was introduced to the fructose permeates of Gluconacetobacter xylinus (ATCC 10,245) bacterial strain to successfully synthesize empty cellulosic pockets for possible drug storage. FTIR Spectroscopy analysis confirmed a slight variation in the hydrogen bonds at 2893 cm(-1) due to CH and CH2 stretching whiles Conformational analysis revealed that inulobiose extending all-trans conformation corresponded to phi = psi = omega = 180 degrees. Fructofuranose moiety, the anomeric carbon was defined as C2. The definition of torsional angles phi = theta(C1-C2-0-CT), psi = theta (C2-0-C1'-C2'), and omega = theta(0-C1'-C2'-0') followed the proposed convention. Glycosidic angle C1'0l'C2' was taken to be 114.0 degrees and both O6 hydroxyl groups in inulobiose were fixed in a trans position, compelling the hydroxyl group to sterically favor comparison with the gauche orientation of sucrose structure. XRD analysis results indicated a typical cellulose type I. DSC and TGA analysis revealed a highly stable pocket until about 260 degrees C.