期刊
CARBOHYDRATE POLYMERS
卷 206, 期 -, 页码 149-162出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.11.002
关键词
Dendrobium huoshanense; Polysaccharides; Intestinal barrier function; Microbiota composition; Intestinal physiological status; Systemic immune response
资金
- National Natural Science Foundation of China [20872024, 21702040]
- Project for Science and Technology Research Plan from Anhui Province of China [15czz04087]
- Fundamental Research Funds for the Central Universities [JZ2017HGPB0169]
The present study investigated the effects of a homogeneous Dendrobium huoshanense polysaccharide (GXG) on mucosal barrier function and microbiota composition in different intestinal regions of mice. Results exhibited, besides changing the intestinal physiological status, orally administrated GXG could improve the intestinal physical barrier function by modulating mucosal structures and up-regulating the expression of tight junction proteins, reinforce the intestinal biochemical barrier function by elevating the expression and secretion of mucin-2, beta-defensins and sIgA, and regulate the intestinal immunological barrier function by stimulating the production of cytokines and the functional development of immune cells. Simultaneously, GXG could differentially impact the composition and metabolism of microbiota along intestinal tract. In addition, the immune response in spleen and peripheral blood were effectively regulated by GXG. These results indicated that GXG might be used as functional agent to improve host health.
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