期刊
CARBOHYDRATE POLYMERS
卷 205, 期 -, 页码 377-384出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.10.076
关键词
Tumor theranostics; Cluster bombs; Superparamagnetic nanoparticles; Tumor-Specific disassembly; On-Demand DOX delivery; Enhanced MR imaging
资金
- Program for New Century Excellent Talents in University of the Ministry of Education of China [NCET-09-0441]
Facile approach was established to fabricate the hybrid cluster bombs of PEGylated chitosan encapsulated doxorubicin (DOX)-loaded superparamagnetic nanoparticles as tumor-specific theranostics for targeted DOX delivery and magnetic resonance (MR) imaging, by simply co-precipitation of poly(ethylene glycol) modified chitosan (CS-PEG), oleylamine modified Fe3O4 (OA-Fe3O4) nanoparticles and DOX. In presence of OA-Fe3O4, the particle size of the DOX/OA-Fe3O4 @CS-PEG cluster bombs decreased to around 80 nm from 300 nm of the DOX/ CS-PEG nanoparticles, with high drug-loading capacity (DLC) of 24.3% and saturation magnetization (Ms) of 4.11 emu/g, respectively. The in vitro evaluation results indicated that the blank OA-Fe3O4 @CS-PEG clusters showed excellent cytocompatibility, while the DOX/OA-Fe3O4 @CS-PEG clusters could be uptaken into HepG2 cells to deliver DOX into the cell nuclei with enhanced anti-cancer efficacy in comparison with free DOX. In the tumor intracellular micro-environment, the stimuli-responsive hybrid cluster bombs disassembled and re-selfassembled into the OA-Fe3O4 nanoparticle clusters with higher Ms for MR imaging-guided diagnosis, owing to the tumor-specific DOX release and dissolution of CS-PEG.
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