4.7 Article

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

期刊

CARBOHYDRATE POLYMERS
卷 206, 期 -, 页码 187-197

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.10.051

关键词

Bacterial cellulose; Ionic liquids; Phenolic acids; Antioxidant properties; Antiinflammatory properties; Skin treatment; Topical applications

资金

  1. FCT/MEC [FCT UID/CTM/50011/2013]
  2. FEDER under the PT2020 Partnership Agreement
  3. FCT [SFRH/593 BD/85871/2012, SFRH/BD/85690/2012]
  4. project AgroForWealth [CENTRO-01-0145-FEDER-000001]
  5. European Research Council (ERC) [ERC 2013-StG-337753]
  6. [IF/01407/2012]
  7. [IF/00402/2015]
  8. Fundação para a Ciência e a Tecnologia [SFRH/BD/85690/2012] Funding Source: FCT

向作者/读者索取更多资源

The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.

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