期刊
CANCER SCIENCE
卷 110, 期 5, 页码 1686-1694出版社
WILEY
DOI: 10.1111/cas.13983
关键词
B-cell malignancy; B-cell non-Hodgkin lymphoma; chronic lymphocytic leukemia; safety; tirabrutinib
类别
资金
- Ono Pharmaceutical Co., Ltd.
We evaluated the safety, efficacy, pharmacokinetics, pharmacodynamics and predictive biomarkers of tirabrutinib, a second-generation, enhanced-selectivity Bruton's tyrosine kinase inhibitor in Japanese patients with relapsed/refractory B-cell non-Hodgkin lymphoma (B-cell NHL) and chronic lymphocytic leukemia (CLL). This was an open-label, multicenter, phase I study. Seventeen patients (male N=8) with a median age of 70years were enrolled in 4 dose cohorts (160mg once daily [N=3], 320mg once daily [N=3], 480mg once daily [N=4] and 300mg twice daily [N=7]); 4 patients had continued tirabrutinib administration as of 4 January 2018. The maximum tolerated dose was not reached. Pneumonitis (N=1) was the dose-limiting toxicity for 300mg twice daily. Common adverse events (AEs) were rash (35.3%) and vomiting (29.4%). Eight patients (47.1%) developed grade3 AEs: neutropenia (23.5%), anemia (11.8%) and leukopenia (11.8%) were frequent. The overall response rate (PR) was 76.5% (13/17 patients), including 4 DLBCL patients with no CD79A/B or MYD88 mutations, and 1 CLL patient with a TP53 mutation, providing promising data for future developments. Of 16 patients with measurable lesions during the screening period, 12 showed 50% reductions in tumor diameter. In many patients, the tumor size decreased soon after beginning treatment. The maximum serum concentration for tirabrutinib was 611, 1220, 1280 and 886ng/mL on Day 1 and 484, 971 1940, and 961ng/mL on Day 28 for Cohorts 1-4, respectively. Tirabrutinib pharmacokinetics were linear, with little accumulation following multiple doses. Tirabrutinib was well tolerated and showed promising efficacy for B-cell NHL/CLL.
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