期刊
CANCER SCIENCE
卷 110, 期 4, 页码 1132-1139出版社
WILEY
DOI: 10.1111/cas.13954
关键词
Epstein-Barr virus; geographic distribution; nasopharyngeal carcinoma; sequencing; strain variation
类别
资金
- Japan Society for the Promotion of Science [15K14391]
- Japan Agency for Medical Research and Development [17fm0208016]
- Grants-in-Aid for Scientific Research [15K14391] Funding Source: KAKEN
Epstein-Barr virus (EBV) is a human tumor virus and is etiologically linked to various malignancies. Certain EBV-associated diseases, such as Burkitt lymphomas and nasopharyngeal carcinomas, are endemic and exhibit biased geographic distribution worldwide. Recent advances in deep sequencing technology enabled high-throughput sequencing of the EBV genome from clinical samples. Rapid cloning and sequencing of cancer-derived EBV genomes, followed by reconstitution of infectious virus, have also become possible. These developments have revealed that various EBV strains are differentially distributed throughout the world, and that the behavior of cancer-derived EBV strains is different from that of the prototype EBV strain of non-cancerous origin. In this review, we summarize recent progress and future perspectives regarding the association between EBV strain variation and cancer.
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