期刊
CANCER PREVENTION RESEARCH
卷 12, 期 4, 页码 237-245出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1940-6207.CAPR-18-0201
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资金
- National Heart, Lung, and Blood Institute, NIH, US Department of Health and Human Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]
- NIH [R01 CA172880, P30 CA125123]
- Gillson Longenbaugh Foundation
- Golfers Against Cancer Organization
- Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center [CIN13-413]
- Global Center for Mass Spectrometry Excellence - Agilent Technologies at BCM [ACS 127430-RSG-15-105-01-CNE, R01CA220297]
- Cancer Prevention and Research Institute of Texas (CPRIT) Proteomics and Metabolomics Core Facility in Dan L Duncan Cancer Center at BCM (Houston, TX) [RP170005]
To examine the association between metabolic deregulation and pancreatic cancer, we conducted a two-stage case-control targeted metabolomics study using prediagnostic sera collected one year before diagnosis in the Women's Health Initiative study. We used the LC/MS to quantitate 470 metabolites in 30 matched case/control pairs. From 180 detectable metabolites, we selected 14 metabolites to be validated in additional 18 matched case/control pairs. We used the paired t test to compare the concentrations of each metabolite between cases and controls and used the log fold change (FC) to indicate the magnitude of difference. FDR adjusted q-value < 0.25 was indicated statistically significant. Logistic regression model and ROC curve analysis were used to evaluate the clinical utility of the metabolites. Among 30 case/control pairs, 1-methyl-L-tryptophan (L-1MT) was significantly lower in the cases than in the controls (log(2) FC = -0.35; q-value = 0.03). The area under the ROC curve was 0.83 in the discrimination analysis based on the levels of L-1MT, acadesine, and aspartic acid. None of the metabolites was validated in additional independent 18 case/control pairs. No significant association was found between the examined metabolites and undiagnosed pancreatic cancer.
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