期刊
CANCER LETTERS
卷 443, 期 -, 页码 67-79出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2018.11.032
关键词
lncRNA; LINC00707-HuR coalition; VAV3; F11R
类别
资金
- National Natural Science Foundation of China [81702340]
- Industrial Technology Innovation Project of Suzhou City [SYS201566]
- Fund for Digestive Diseases and Nutrition Research key Laboratory of Suzhou [SZS201620]
Multiple studies have revealed that long non-coding RNAs (IncRNAs) extensively participate in human cancer malignant progression. The long intergenic non-protein coding RNA 707 (LINC00707), 3087 by in length, was recently reported to be an essential oncogene in promoting lung adenocarcinoma cell proliferation and metastasis, However, its role in gastric cancer (GC) remains unclear. In this study, we identified that LINC00707 was excessively expressed in GC tissues and correlated with advanced stage, larger tumor size, lymph node metastasis and poorer prognosis in GC patients. In vitro and in vivo assays showed that LINC00707 promote GC cell proliferation and metastasis. Mechanistically, LINC00707 could abundantly interact with mRNA stabilizing protein HuR; LINC00707-HuR coalition ulteriorly combined with VAV3/F11R, mRNAs and increased their stability. Taken together, our findings prove that LINC00707 may act as an oncogene in GC by regulating mRNA stability and serve as a potential target for GC diagnosis and prognosis.
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