期刊
CANCER INVESTIGATION
卷 37, 期 3, 页码 144-155出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357907.2019.1582060
关键词
Glioblastoma; Cancer stem cells; Dynamin; Cancer biology; Invasion
类别
资金
- Royal Melbourne Hospital Neuroscience Foundation
- ARC Discovery Project
- NHMRC Project grant
Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied about cell viability, and GSC neurosphere formation in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.
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