期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 185, 期 3, 页码 503-513出版社
WILEY
DOI: 10.1111/bjh.15803
关键词
immune thrombocytopenia; newly diagnosed; persistent; thrombopoietin; romiplostim
类别
The thrombopoietin receptor agonist romiplostim is approved for second-line use in chronic immune thrombocytopenia (ITP), but its effects in patients with ITP for <= 1 year are not well characterized. This analysis of pooled data from 9 studies included patients with ITP for <= 1 year (n = 311) or >1 year (n = 726) who failed first-line treatments and received romiplostim, placebo or standard of care. In subgroup analysis by ITP duration, patient incidences for platelet response at >= 75% of measurements were higher for romiplostim [ITP <= 1 year: 74% (204/277); ITP >1 year: 71% (450/634)] than for placebo/standard of care [ITP <= 1 year: 18% (6/34); ITP >1 year: 9% (8/92)]. Of patients with >= 9 months on study, 16% with ITP <= 1 year and 6% with ITP >1 year discontinued romiplostim and maintained platelet counts >= 50 x 10(9)/l for >= 6 months without ITP treatment (treatment-free remission). Independent of ITP duration, rates of serious adverse events and bleeding were lower with romiplostim than placebo/standard of care and thrombotic events occurred at similar rates. In this analysis, romiplostim and placebo/standard of care had similar safety profiles and romiplostim increased platelet counts in patients with either ITP <= 1 year or ITP >1 year, with more treatment-free remission in those with ITP <= 1 year.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据