期刊
BRAIN STRUCTURE & FUNCTION
卷 224, 期 4, 页码 1505-1518出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00429-019-01845-5
关键词
Basal forebrain; Parvalbumin; Gamma oscillations; Auditory steady-state response (ASSR); Optogenetic high-density EEG
资金
- U.S. Veterans Administration
- US National Institutes of Health [RO1 MH039683, R01 MH100820, R21 NS079866, R21 NS093000]
- National Research Council of Science and technology of Korea [CRC-15-04-KIST]
- National Research Foundation of Korea [2017R1A2B3012659]
- United States VA Biomedical Laboratory Research and Development Service Award [I01BX001356]
- VA CDA [IK2BX002130]
- National Research Foundation of Korea [2017R1A2B3012659] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
High-density electroencephalographic (hdEEG) recordings are widely used in human studies to determine spatio-temporal patterns of cortical electrical activity. How these patterns of activity are modulated by subcortical arousal systems is poorly understood. Here, we couple selective optogenetic stimulation of a defined subcortical cell-type, basal forebrain (BF) parvalbumin (PV) neurons, with hdEEG recordings in mice (Opto-hdEEG). Stimulation of BF PV projection neurons preferentially generated time-locked gamma oscillations in frontal cortices. BF PV gamma-frequency stimulation potently modulated an auditory sensory paradigm used to probe cortical function in neuropsychiatric disorders, the auditory steady-state response (ASSR). Phase-locked excitation of BF PV neurons in advance of 40Hz auditory stimuli enhanced the power, precision and reliability of cortical responses, and the relationship between responses in frontal and auditory cortices. Furthermore, synchronization within a frontal hub and long-range cortical interactions were enhanced. Thus, phasic discharge of BF PV neurons changes cortical processing in a manner reminiscent of global workspace models of attention and consciousness.
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