期刊
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12906-019-2446-3
关键词
National Health Insurance Research Database; Osteoporotic fracture; Traditional Chinese medicine
资金
- Taiwan Ministry of Health and Welfare Clinical Trial Center [MOHW106-TDU-B-212-113004]
- China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project [BM10601010036]
- Taiwan Clinical Trial Consortium for Stroke [MOST 106-2321-B-039-005]
- Tseng-Lien Lin Foundation, Taichung, Taiwan
- Taiwan Brain Disease Foundation, Taipei, Taiwan
- Katsuzo and Kiyo Aoshima Memorial Funds, Japan
BackgroundThere are no published studies regarding the efficacy of traditional Chinese medicine (TCM) for the prevention of osteoporotic fracture. Therefore, we conducted this nationwide, population-based cohort study to investigate the probable effect of TCM to decrease the fracture rate.MethodsWe identified cases with osteoporosis and selected a comparison group that was frequency-matched according to sex, age (per 5years), diagnosis year of osteoporosis, and index year. The difference between the two groups in the development of fracture was estimated using the Kaplan-Meier method and the log-rank test.ResultsAfter inserting age, gender, urbanization level, and comorbidities into the Cox's proportional hazard model, patients who used TCM had a lower hazard ratio (HR) of fracture (adjusted HR: 0.47, 95% CI: 0.37-0.59) compared to the non-TCM user group. The Kaplan-Meier curves showed that osteoporosis patients who used TCM had a lower incidence of fracture events than those who did not (p<0.00001). Our study also demonstrated that the longer the TCM use, the lesser the fracture rate.ConclusionOur study showed that TCM might have a positive impact on the prevention of osteoporotic fracture.
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