期刊
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
卷 24, 期 1, 页码 48-64出版社
KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
DOI: 10.1007/s12257-018-0346-x
关键词
Klebsiella pneumoniae; biorefinery; metabolic engineering; microbial cell factory; carbon utilization; biomass
资金
- Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) of Korea [NRF-2015M1A2A2035810]
- Bio & Medical Technology Development Program MSIT through the NRF of Korea [NRF-2018M3A9H3020459]
- Korea Institute of Energy Technology Evaluation and Planning (KETEP) from the Ministry of Trade, Industry & Energy, Republic of Korea [20174010201150]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20174010201150] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society's dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.
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