期刊
BIOTECHNOLOGY ADVANCES
卷 37, 期 2, 页码 340-353出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2019.01.008
关键词
Phycobiliprotein; Structure and function; Biosynthesis; Purification; Oxidative stress; Anti-tumor effect
资金
- National Key Research and Development Program of China [2018YFD0901102]
- UK Royal Society [UF120411, URF\R\180030]
- Biotechnology and Biological Sciences Research Council [BB/M024202/1, BB/R003890/1]
- BBSRC [BB/M024202/1, BB/R003890/1] Funding Source: UKRI
Phycobiliproteins (PBPs) are the main component of light-harvesting complexes in cyanobacteria and red algae. In addition to their important role in photosynthesis, PBPs have many potential applications in foods, cosmetics, medical diagnosis and treatment of diseases. However, basic researches and technological innovations are urgently needed for exploring those potentials, such as structure and function, their biosynthesis as well as downstream purification. For medical use and application, mechanisms underlying their therapeutic effects must be elucidated. Focusing on these issues, this article gives a critical review on the current status on PBPs, including their structures and functions, preparation processes and applications. In addition, key technical challenges and possible solutions are prospected.
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