期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 83, 期 7, 页码 1329-1335出版社
OXFORD UNIV PRESS
DOI: 10.1080/09168451.2019.1597617
关键词
Difructose anhydride III; bile acid; deconjugation; 7 alpha-dehydroxylation
类别
资金
- Japan Society for the Promotion of Science [16K14917]
- Grants-in-Aid for Scientific Research [16K14917] Funding Source: KAKEN
Difructose anhydride III (DFAIII) is a prebiotic involved in the reduction of secondary bile acids (BAs). We investigated whether DFAIII modulates BA metabolism, including enterohepatic circulation, in the rats fed with a diet supplemented with cholic acid (CA), one of the 12 alpha-hydroxylated BAs. After acclimation, the rats were fed with a control diet or a diet supplemented with DFAIII. After 2 weeks, each group was further divided into two groups and was fed diet with or without CA supplementation at 0.5 g/kg diet. BA levels were analyzed in aortic and portal plasma, liver, intestinal content, and feces. As a result, DFAIII ingestion reduced the fecal deoxycholic acid level via the partial suppression of deconjugation and 7 alpha-dehydroxylation of BAs following CA supplementation. These results suggest that DFAIII suppresses production of deoxycholic acid in conditions of high concentrations of 12 alpha-hydroxylated BAs in enterohepatic circulation, such as obesity or excess energy intake.
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