期刊
BIOORGANIC CHEMISTRY
卷 87, 期 -, 页码 613-628出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2019.03.060
关键词
Betulin; Phosphate; Crystal structure; Molecular docking; Anticancer
资金
- National Science Centre, Poland [2015/18/M/ST5/00060]
- Wroclaw Centre for Networking and Supercomputing [382]
Betulin derivatives exhibit an antiproliferative activity and have been tested for many cancer cell lines. This paper describes a new series of 3-phosphate derivatives of betulin bearing different substituents at C28 position. The synthesized compounds were tested in vitro for their antiproliferative effect against human leukemia (MV-4-11 and CCRF/CEM), lung carcinoma (A549), prostate cancer (DU 145), melanoma (Hs 294T) cell lines, and murine leukemia P388. To explore the possible mechanism of anticancer activity for the most in vitro active compounds (4, 5, 7 and 8) and betulin, molecular docking was performed to the binding sites of potential anticancer targets, described for the various triterpene derivatives, including topoisomerase I and II, epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGFR), transcription factor NF-kappa B, antiapoptotic protein Bcl-2 and peroxisome proliferator-activated receptor (PPAR gamma). According to the results of the docking, the best fit to the binding pocket of PPAR gamma was shown by compound 4.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据