期刊
BIOESSAYS
卷 41, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/bies.201800199
关键词
Alzheimer's disease; cell therapy; exosomes; extracellular vesicles; mesenchymal stem cells; microvesicles; personalized medicine
资金
- Regione Lombardia [239047, CUP E47F17000000009, CUP_B42F16000440005, KMN142, KMN153]
No cure yet exists for devastating Alzheimer's disease (AD), despite many years and humongous efforts to find efficacious pharmacological treatments. So far, neither designing drugs to disaggregate amyloid plaques nor tackling solely inflammation turned out to be decisive. Mesenchymal stem cells (MSCs) and, in particular, extracellular vesicles (EVs) originating from them could be proposed as an alternative, strategic approach to attack the pathology. Indeed, MSC-EVs-owing to their ability to deliver lipids/proteins/enzymes/microRNAs endowed with anti-inflammatory, amyloid-beta degrading, and neurotrophic activities-may be exploited as therapeutic tools to restore synaptic function, prevent neuronal death, and slow down memory impairment in AD. Herein the results presented in the most recently published studies on this topic are critically evaluated, providing a strong rationale for possible employment of MSC-EVs in AD. Also see the video abstract here .
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