期刊
BIOESSAYS
卷 41, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/bies.201800194
关键词
CKAP5; cytoskeleton; doublecortin; end-binding proteins; microtubule; microtubule dynamics
资金
- NCRR NIH HHS [S10 RR026758] Funding Source: Medline
- NINDS NIH HHS [R01 NS107480] Funding Source: Medline
Microtubules form a highly dynamic filament network in all eukaryotic cells. Individual microtubules grow by tubulin dimer subunit addition and frequently switch between phases of growth and shortening. These unique dynamics are powered by GTP hydrolysis and drive microtubule network remodeling, which is central to eukaryotic cell biology and morphogenesis. Yet, our knowledge of the molecular events at growing microtubule ends remains incomplete. Here, recent ultrastructural, biochemical and cell biological data are integrated to develop a realistic model of growing microtubule ends comprised of structurally distinct but biochemically overlapping zones. Proteins that recognize microtubule lattice conformations associated with specific tubulin guanosine nucleotide states may independently control major structural transitions at growing microtubule ends. A model is proposed in which tubulin dimer addition and subsequent closure of the MT wall are optimized in cells to achieve rapid physiological microtubule growth.
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