4.7 Article

Graphene-ferrocene functionalized cyclodextrin composite with high electrochemical recognition capability for phenylalanine enantiomers

期刊

BIOELECTROCHEMISTRY
卷 128, 期 -, 页码 74-82

出版社

ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2019.03.006

关键词

Chiral recognition; beta-Cyclodextrin; Graphene; Composite; Phenylalanine enantiomers

资金

  1. National Natural Science Foundation of China [51262027]
  2. State Key Laboratory of Solidification Processing in NWPU [SKLSP201754]
  3. Science and Technology Project Gansu Province [17YF1GA017, 17JR5RA082]
  4. Research Project of Higher Education in Gansu Province [2017A-002]

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Graphene oxide (GO) modified with ferrocene (Fc) was successfully assembled via the pi-pi interaction (GO-Fc) and had the features of large surface area and high loading. Then, a novel composite was synthesized via beta-cyclodextrin (beta-CD) functionalized GO-Fc by combining the advantages of GO-Fc and beta-CD. An efficient chiral electrochemical sensing interface was constructed by using the rGO-Fc-CD composite as the electrode modification for the recognition of phenylalanine (Phe) enantiomers. The successful synthesis of the composites was confirmed by FIR, XRD, TGA, SEM, and XPS results. The host-guest inclusion interaction was detected by ultraviolet spectroscopy and DPV. The recognition results demonstrated that the rGO-Fc-CD/GCE showed a higher chiral recognition capability for L-Phe than for D-Phe. The enantioselectivity coefficient (I-D/I-L) of the proposed sensor was 2.47. The LOD values of 27 nM and 52 nM (S/N = 3) for L-Phenylalanine and D-Phenylalanine were obtained for this electrochemical sensor. The as-synthesized material was successfully exploited for the recognition of Phe enantiomers, indicating that the developed sensor has wide application prospects. (C) 2019 Elsevier B.V. All rights reserved.

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