4.5 Review

From APOBEC to ZAP: Diverse mechanisms used by cellular restriction factors to inhibit virus infections

期刊

出版社

ELSEVIER
DOI: 10.1016/j.bbamcr.2018.09.012

关键词

Interferon stimulated gene; Virus infection; Restriction factor

资金

  1. NIH [AI130110, AI104483]
  2. Ohio State University Systems and Integrative Biology Training Program - NIH [GM068412]
  3. Ohio State University Interdisciplinary Program in Microbe-Host Interactions - NIH [AI112542]
  4. Ohio State University College of Medicine
  5. Gilliam Predoctoral Fellowship from the Howard Hughes Medical Institute

向作者/读者索取更多资源

Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of viruses. These proteins are critical components of the innate immune system and function to limit the severity and host range of virus infections. Here we review the current knowledge on the mechanisms of action of several restriction factors that affect multiple viruses at distinct stages of their life cycles. For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation. We also discuss countermeasures employed by specific viruses against these restriction factors, and mention secondary functions of several of these factors in modulating immune responses. These important examples highlight the diverse strategies cells have evolved to combat virus infections.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据