期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1865, 期 3, 页码 620-633出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2018.12.015
关键词
Zebrafish; Hematopoiesis; Leukemia models; Xenotransplantation; Chemical screens
资金
- BTL Banca del Territorio Lombardo
- Lions Bassa Bresciana Foundation
- Associazione Italiana per la Ricerca sul Cancro (AIRC) IG grant [18493]
Zebrafish (Danio rerio) has proven to be a versatile and reliable in vivo experimental model to study human hematopoiesis and hematological malignancies. As vertebrates, zebrafish has significant anatomical and biological similarities to humans, including the hematopoietic system. The powerful genome editing and genome-wide forward genetic screening tools have generated models that recapitulate human malignant hematopoietic pathologies in zebrafish and unravel cellular mechanisms involved in these diseases. Moreover, the use of zebrafish models in large-scale chemical screens has allowed the identification of new molecular targets and the design of alternative therapies. In this review we summarize the recent achievements in hematological research that highlight the power of the zebrafish model for discovery of new therapeutic molecules. We believe that the model is ready to give an immediate translational impact into the clinic.
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