期刊
BIOCHEMICAL PHARMACOLOGY
卷 165, 期 -, 页码 126-133出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2019.03.017
关键词
Senescence; Therapies; Osteoarthritis; Osteoporosis; Rheumatology
资金
- national transversal Project INSERM AgeMed
- Foreum program SenOA
- Montpellier Hospital
- F.R.S. - F.N.R.S.
Over the past years, through in vitro studies and unique animal models, biologists and clinicians have demonstrated that cellular senescence is at the root of numerous age-related chronic diseases including osteoarthritis and osteoporosis. This non-proliferative cellular syndrome can modify other surrounding tissue-resident cells through the establishment of a deleterious catabolic and inflammatory microenvironment. Targeting these deleterious cells through local or systemic seno-therapeutic agent delivery in pre-clinical models improves dramatically clinical signs and extends health span. In this review, we will summarize the current knowledge on cellular senescence, list the different strategies for identifying seno-suppressive therapeutic agents and their translations to rheumatic diseases.
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