期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 15, 期 -, 页码 695-702出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.15.64
关键词
Clavularia viridis; Lemnalia flava; NF-kappa B; PTP1B; sesquiterpenoid; soft coral; terpenes
资金
- National Key Research and Development Program of China [2018YFC0310903]
- Natural Science Foundation of China [21672230, 81603022, 81125023]
- SKLDR/SIMM Projects [SIMM 1705ZZ-01]
A detailed chemical investigation of the South China Sea soft corals Clavularia viridis and Lemnalia flava yielded four new halogenated laurane-type sesquiterpenoids, namely, isobromolaurenisol (1), clalaurenol A (2), ent-laurenisol (3), clalaurenol B (4), and the new aromadendrane-type sesquiterpenoid claaromadendrene (6), together with three known sesquiterpenoids (5, 7, and 8). Their structures were determined by extensive spectroscopic analysis and by comparison with the previously reported analogues. In a bioassay, compounds 1, 2 and 4 exhibited interesting inhibitory activities in vitro against PTP1B and NF-kappa B.
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