期刊
AVIAN PATHOLOGY
卷 48, 期 3, 页码 238-244出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/03079457.2019.1572103
关键词
Mycoplasma gallisepticum; vaccine; live vaccine; protection; comparison; efficacy; MB; modified Frey's mycoplasma broth; MG; Mycoplasma gallisepticum; NV; Non-vaccinated; PCR; polymerase chain reaction; RSA; rapid serum agglutination; SPF; specific-pathogen-free; SD; standard deviation
资金
- Bioproperties Australia Pty Ltd.
In order to compare the short-term efficacies of the live attenuated Mycoplasma gallisepticum (MG) vaccine strains ts-11 and 6/85, four groups of SPF chickens were vaccinated with each of the vaccines using eye drop and aerosol inoculations, and were subsequently challenged with a wild-type MG strain. When administered by the recommended routes (eye drop for ts-11 and fine aerosol for 6/85), both vaccines induced substantial and comparable levels of protection against airsacculitis and tracheitis caused by wild-type MG. The long-term efficacies of the two vaccines administered by the recommended route were also assessed. Serum antibody responses and colonization of the vaccines in the upper respiratory system were monitored at different time points after vaccination, and protective efficacies of the vaccines were evaluated at 36 weeks post vaccination as above. Systemic antibody response following ts-11 eye drop vaccination was initially strong but reduced gradually over time while, in contrast, that to 6/85 spray vaccination was initially weak but increased over time. Kinetics of the antibody response to the vaccines appeared to be correlated with the number of birds harbouring each vaccine in their upper respiratory system throughout the sampling timepoints. Regardless of the levels of serum antibodies or number of birds harbouring the vaccine, both vaccines induced substantial and comparable levels of protection against airsacculitis and tracheitis caused by wild-type MG. Therefore, kinetics of systemic antibody response and persistence in the upper respiratory system varies between vaccine strains; however, the levels of protection may not, at least up to 36 weeks post vaccination.
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