期刊
ANNUAL REVIEW OF NEUROSCIENCE, VOL 42
卷 42, 期 -, 页码 67-86出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-neuro-070918-050428
关键词
hair cell; cochlea; auditory hindbrain; auditory cortex; evolution; gene regulatory networks
The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms underlying the development of the peripheral auditory system, the cochlea and its afferent auditory neurons, and how this system extracts the physical parameters of sound. Although this genetic dissection has provided little information about the central auditory system, scattered data suggest that some genes may have a critical role in both the peripheral and central auditory systems. Here, we review the genes controlling the development and function of the peripheral and central auditory systems, focusing on those with demonstrated intrinsic roles in both systems and highlighting the current underappreciation of these genes. Their encoded products are diverse, from transcription factors to ion channels, as are their roles in the central auditory system, mostly evaluated in brainstem nuclei. We examine the ontogenetic and evolutionary mechanisms that may underlie their expression at different sites.
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