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PLOS ONE (2014)
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SCIENCE (2014)
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TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
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ORGANOGENESIS (2014)
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CELL REPORTS (2014)
Concise Review: Drug Discovery in the Age of the Induced Pluripotent Stem Cell
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STEM CELLS TRANSLATIONAL MEDICINE (2014)
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H. M. Chen et al.
TRANSLATIONAL PSYCHIATRY (2014)
International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper
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STEM CELL REPORTS (2014)
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FRONTIERS IN PEDIATRICS (2014)
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ACTA NEUROPATHOLOGICA (2013)
Cerebral Organoids in a Dish: Progress and Prospects
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CELL (2013)
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
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CELL STEM CELL (2013)
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CELL STEM CELL (2013)
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CELL STEM CELL (2013)
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Asif M. Maroof et al.
CELL STEM CELL (2013)
Modeling Alzheimer's Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
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CELL STEM CELL (2013)
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Lutz Garbes et al.
HUMAN MOLECULAR GENETICS (2013)
Tau Pathology as a Cause and Consequence of the UPR
Brian J. Stoveken
JOURNAL OF NEUROSCIENCE (2013)
Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells
Mackenzie W. Amoroso et al.
JOURNAL OF NEUROSCIENCE (2013)
Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation
Jose F. Abisambra et al.
JOURNAL OF NEUROSCIENCE (2013)
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Matthew F. Burkhardt et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2013)
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Clifford R. Jack et al.
LANCET NEUROLOGY (2013)
Cerebral organoids model human brain development and microcephaly
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NATURE (2013)
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NATURE PROTOCOLS (2013)
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NATURE PROTOCOLS (2013)
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NATURE REVIEWS DRUG DISCOVERY (2013)
Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions
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NEURO-ONCOLOGY (2013)
Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients
Leonidas Chouliaras et al.
NEUROBIOLOGY OF AGING (2013)
Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
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NEURON (2013)
Biomarker Modeling of Alzheimer's Disease
Clifford R. Jack et al.
NEURON (2013)
Use of ''MGE Enhancers'' for Labeling and Selection of Embryonic Stem Cell-Derived Medial Ganglionic Eminence (MGE) Progenitors and Neurons
Ying-Jiun J. Chen et al.
PLOS ONE (2013)
A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1
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PLOS ONE (2013)
Genomic responses in mouse models poorly mimic human inflammatory diseases
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons
Chee Yeun Chung et al.
SCIENCE (2013)
Mosaic Copy Number Variation in Human Neurons
Michael J. McConnell et al.
SCIENCE (2013)
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Dhruv Sareen et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
Eloise Hudry et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
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Xiaohong Xu et al.
STEM CELL RESEARCH (2013)
Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells
Claire N. Medine et al.
STEM CELLS TRANSLATIONAL MEDICINE (2013)
Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells
Helen Fong et al.
STEM CELL REPORTS (2013)
Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell-Derived Neuroepithelial-like Stem Cells
Donna McLaren et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
Using Human Pluripotent Stem Cell-Derived Dopaminergic Neurons to Evaluate Candidate Parkinson's Disease Therapeutic Agents in MPP+ and Rotenone Models
Jun Peng et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
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Kristen J. Brennand et al.
DISEASE MODELS & MECHANISMS (2012)
Locus-specific mutation databases for neurodegenerative brain diseases
Marc Cruts et al.
HUMAN MUTATION (2012)
Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform
Antje D. Ebert et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2012)
Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations
N. Farra et al.
MOLECULAR PSYCHIATRY (2012)
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Mason A. Israel et al.
NATURE (2012)
Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression
Gabsang Lee et al.
NATURE BIOTECHNOLOGY (2012)
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NATURE NEUROSCIENCE (2012)
DISEASE MECHANISMS Genetic architectures of psychiatric disorders: the emerging picture and its implications
Patrick F. Sullivan et al.
NATURE REVIEWS GENETICS (2012)
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
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Rosa Rademakers et al.
NATURE REVIEWS NEUROLOGY (2012)
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Bilada Bilican et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders
Brian J. O'Roak et al.
SCIENCE (2012)
Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
Naohiro Egawa et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Oliver Cooper et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
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Iksoo Jeon et al.
STEM CELLS (2012)
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Sofia B. Leite et al.
TOXICOLOGICAL SCIENCES (2012)
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Sheng Chih Jin et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects
Sandra Almeida et al.
CELL REPORTS (2012)
Drug Discovery Models and Toxicity Testing Using Embryonic and Induced Pluripotent Stem-Cell-Derived Cardiac and Neuronal Cells
Rahul S. Deshmukh et al.
STEM CELLS INTERNATIONAL (2012)
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Youssef Hibaoui et al.
FRONTIERS IN PHYSIOLOGY (2012)
A High-Throughput Screen for Wnt/β-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors
Wen-Ning Zhao et al.
JOURNAL OF BIOMOLECULAR SCREENING (2012)
The Human Brain in a Dish: The Promise of iPSC-Derived Neurons
Ricardo Dolmetsch et al.
CELL (2011)
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
Ha Nam Nguyen et al.
CELL STEM CELL (2011)
Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions
Rajesh Ambasudhan et al.
CELL STEM CELL (2011)
Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
Esther Y. Son et al.
CELL STEM CELL (2011)
The Use of Induced Pluripotent Stem Cells in Drug Development
H. Inoue et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Synaptic Wnt signaling-a contributor to major psychiatric disorders?
Nathan D. Okerlund et al.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS (2011)
Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells
Erika Pedrosa et al.
JOURNAL OF NEUROGENETICS (2011)
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C-H Chiang et al.
MOLECULAR PSYCHIATRY (2011)
Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes
Mark E. Hester et al.
MOLECULAR THERAPY (2011)
Modelling schizophrenia using human induced pluripotent stem cells
Kristen J. Brennand et al.
NATURE (2011)
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Andrew S. Yoo et al.
NATURE (2011)
Induction of human neuronal cells by defined transcription factors
Zhiping P. Pang et al.
NATURE (2011)
A screen for regulators of survival of motor neuron protein levels
Nina R. Makhortova et al.
NATURE CHEMICAL BIOLOGY (2011)
Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome
Sergiu P. Pasca et al.
NATURE MEDICINE (2011)
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Keisuke Okita et al.
NATURE METHODS (2011)
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PLOS ONE (2011)
Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome
Steven D. Sheridan et al.
PLOS ONE (2011)
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
Wenlin Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome
Kun-Yong Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
Sebastien Jacquemont et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
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Shiva Nemati et al.
STEM CELLS AND DEVELOPMENT (2011)
Clinical Progression in Parkinson Disease and the Neurobiology of Axons
Hsiao-Chun Cheng et al.
ANNALS OF NEUROLOGY (2010)
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Ivana Barbaric et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2010)
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Maria C. N. Marchetto et al.
CELL (2010)
Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors
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CELL (2010)
Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
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Luigi Warren et al.
CELL STEM CELL (2010)
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Shoji Tsuji
HUMAN MOLECULAR GENETICS (2010)
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Maria C. N. Marchetto et al.
HUMAN MOLECULAR GENETICS (2010)
High-throughput Screening in Embryonic Stem Cell-derived Neurons Identifies Potentiators of α-Amino-3-hydroxyl-5-methyl-4-isoxazolepropionate-type Glutamate Receptors
John McNeish et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Direct conversion of fibroblasts to functional neurons by defined factors
Thomas Vierbuchen et al.
NATURE (2010)
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Michael L. Metzker
NATURE REVIEWS GENETICS (2010)
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Evan T. Powers et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
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Teemu J. Heikkila et al.
EXPERIMENTAL NEUROLOGY (2009)
Human Embryonic Stem Cell Technologies and Drug Discovery
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JOURNAL OF CELLULAR PHYSIOLOGY (2009)
FLEXIQuant: A Novel Tool for the Absolute Quantification of Proteins, and the Simultaneous Identification and Quantification of Potentially Modified Peptides
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JOURNAL OF PROTEOME RESEARCH (2009)
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Stuart M. Chambers et al.
NATURE BIOTECHNOLOGY (2009)
Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
Noemi Fusaki et al.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2009)
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration
Philipp Koch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
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SCIENCE (2009)
The heritability and genetics of frontotemporal lobar degeneration
J. D. Rohrer et al.
NEUROLOGY (2009)
The global burden of mental disorders: An update from the WHO World Mental Health (WMH) Surveys
Ronald C. Kessler et al.
EPIDEMIOLOGIA E PSICHIATRIA SOCIALE-AN INTERNATIONAL JOURNAL FOR EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES (2009)
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Sabrina C. Desbordes et al.
CELL STEM CELL (2008)
Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation
Francesco Paolo Di Giorgio et al.
CELL STEM CELL (2008)
Induced Pluripotent Stem Cells Generated Without Viral Integration
Matthias Stadtfeld et al.
SCIENCE (2008)
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
John T. Dimos et al.
SCIENCE (2008)
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SCIENCE (2007)
Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
Kunihiro Uryu et al.
EXPERIMENTAL NEUROLOGY (2007)
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
Kazutoshi Takahashi et al.
CELL (2007)
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Nuria Flames et al.
JOURNAL OF NEUROSCIENCE (2007)
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
Hao Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage
Blaine W. Phillips et al.
STEM CELLS AND DEVELOPMENT (2007)
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Kiichi Watanabe et al.
NATURE BIOTECHNOLOGY (2007)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
L3/Lhx8 is involved in the determination of cholinergic or GABAergic cell fate
T Manabe et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice
H Ryu et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Specification of motoneurons from human embryonic stem cells
XJ Li et al.
NATURE BIOTECHNOLOGY (2005)
Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders
C Rouaux et al.
BIOCHEMICAL PHARMACOLOGY (2004)
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
S Prabakaran et al.
MOLECULAR PSYCHIATRY (2004)
Paradigm shifts in Alzheimer's disease and other neuro degenerative disorders: The emerging role of oligomeric assemblies
MD Kirkitadze et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2002)
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JS Odorico et al.
STEM CELLS (2001)
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BE Reubinoff et al.
NATURE BIOTECHNOLOGY (2000)