期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 24, 页码 8226-8230出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900926
关键词
2-oxoglutarate-dependent dioxygenases; biocatalysis; lignans; podophyllotoxin; total synthesis
资金
- Austrian Science Fund (FWF) [P 31276-B21]
- Austrian FFG
- BMWFJ
- ZIT through the Austrian FFG-COMET Funding Program
- BMVIT
- SFG
- Standortagentur Tirol
Podophyllotoxin is probably the most prominent representative of lignan natural products. Deoxy-, epi-, and podophyllotoxin, which are all precursors to frequently used chemotherapeutic agents, were prepared by a stereodivergent biotransformation and a biocatalytic kinetic resolution of the corresponding dibenzylbutyrolactones with the same 2-oxoglutarate-dependent dioxygenase. The reaction can be conducted on 2 g scale, and the enzyme allows tailoring of the initial, natural structure and thus transforms various non-natural derivatives. Depending on the substitution pattern, the enzyme performs an oxidative C-C bond formation by C-H activation or hydroxylation at the benzylic position prone to ring closure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据