期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 22, 页码 7259-7262出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900139
关键词
dynamic nuclear polarization; electron decoupling; electron saturation recovery; magic angle spinning; NMR spectroscopy
资金
- National Institute of Health (NIH) [DP2-GM119131]
- National Science Foundation [CAREER DBI-1553577]
- Camille Dreyfus Teacher-Scholar Awards Program
Dynamic nuclear polarization (DNP) increases NMR sensitivity by transferring polarization from electron to nuclear spins. Herein, we demonstrate that electron decoupling with chirped microwave pulses enables improved observation of DNP-enhanced C-13 spins in direct dipolar contact with electron spins, thereby leading to an optimal delay between transients largely governed by relatively fast electron relaxation. We report the first measurement of electron longitudinal relaxation time (T-1e) during magic angle spinning (MAS) NMR by observation of DNP-enhanced NMR signals (T-1e=40 +/- 6ms, 40mM trityl, 4.0kHz MAS, 4.3K). With a 5ms DNP period, electron decoupling results in a 195% increase in signal intensity. MAS at 4.3K, DNP, electron decoupling, and short recycle delays improve the sensitivity of C-13 in the vicinity of the polarizing agent. This is the first demonstration of recovery times between MAS-NMR transients being governed by short electron T-1 and fast DNP transfer.
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