4.8 Article

A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 18, 页码 6064-6069

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900011

关键词

analyte enrichment; biofluids; lipid isomers; mass spectrometry; polymer coatings

资金

  1. National Natural Science Foundation of China [21874081, 21627807]
  2. US National Institutes of Health [R01GM118484, R44GM119584, R01AI122932, 1R01AI122298]

向作者/读者索取更多资源

A porous polymer coating transfer enrichment method is developed for the direct mass spectrometry (MS) analysis of lipids. The enrichment is fast (ca. 1min) and enables the profiling and quantitation of lipids in small-volume biofluid samples. Coupled with a photochemical Patern-Buchi reaction, this method enables the fast determination of lipid structure at the C=C location level and point-of-care lipid biomarker analysis.

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