期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 18, 页码 6064-6069出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900011
关键词
analyte enrichment; biofluids; lipid isomers; mass spectrometry; polymer coatings
资金
- National Natural Science Foundation of China [21874081, 21627807]
- US National Institutes of Health [R01GM118484, R44GM119584, R01AI122932, 1R01AI122298]
A porous polymer coating transfer enrichment method is developed for the direct mass spectrometry (MS) analysis of lipids. The enrichment is fast (ca. 1min) and enables the profiling and quantitation of lipids in small-volume biofluid samples. Coupled with a photochemical Patern-Buchi reaction, this method enables the fast determination of lipid structure at the C=C location level and point-of-care lipid biomarker analysis.
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