期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 18, 页码 5994-6000出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901525
关键词
imaging agents; glomerular filtration rate; nanoparticles; photoacoustic imaging; renal function
资金
- NIH [R01DK103363, R01DK115986, NIH 1 S10 OD018094-01A1]
- Welch Research Foundation [AT-1974-20180324]
- University of Texas at Dallas
- Harold C. Simmons Cancer Center through the NCI Cancer Center Support Grant [1P30 CA142543]
Noninvasive monitoring of kidney elimination of engineered nanoparticles at high temporal and spatial resolution will not only significantly advance our fundamental understandings of nephrology on the nanoscale, but also aid in the early detection of kidney disease, which affects more than 10% of the worldwide population. Taking advantage of strong NIR absorption of the well-defined Au-25(SG)(18) nanocluster, photoacoustic (PA) imaging was used to visualize its transport insitu through the aorta to the renal parenchyma and its subsequent filtration into the renal pelvis at a temporal resolution down to 1s. High temporal and spatial resolution imaging of Au-25(SG)(18) kidney elimination allowed the accurate quantification of the glomerular filtration rate (GFR) of individual kidneys in normal and pathological conditions, broadening the biomedical applications of engineered nanoparticles in preclinical kidney research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据