期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 20, 页码 6732-6736出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901619
关键词
alkynes; axial chirality; C-H activation; heterocycles; rhodium
资金
- National Natural Science Foundation of China [21402244]
The first enantioselective Satoh-Miura-type reaction is reported. A variety of C-N axially chiral N-aryloxindoles have been enantioselectively synthesized by an asymmetric rhodium-catalyzed dual C-H activation reaction of N-aryloxindoles and alkynes. High yields and enantioselectivities were obtained (up to 99% yield and up to 99% ee). To date, it is also the first example of the asymmetric synthesis of C-N axially chiral compounds by such a C-H activation strategy.
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