期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 21, 页码 7117-7121出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201901733
关键词
allylic amidation; branch-selective reactions; carboxylic acids; C-H activation; redox-neutral reactions
资金
- Deutsche Forschungsgemeinschaft [SFB 858]
Herein, we report the redox-neutral, intermolecular, and highly branch-selective amidation of allylic C-H bonds enabled by Cp*Ir-III catalysis. A variety of readily available carboxylic acids were converted into the corresponding dioxazolones and efficiently coupled with terminal and internal olefins in high yields and selectivities. Mechanistic investigations support the formation of a nucleophilic Ir-III-allyl intermediate rather than the direct insertion of an Ir-nitrenoid species into the allylic C-H bond.
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