期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 12, 页码 4002-4006出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201812227
关键词
amines; photochemistry; radicals; reaction mechanisms; synthetic methods
资金
- NIGMS [GM125206]
- Croucher Foundation
The synthetic utility of tertiary amines to oxidatively generate a-amino radicals is well established, however, primary amines remain challenging because of competitive side reactions This report describes the site-selective a-functionalization of primary amine derivatives through the generation of a-amino radical intermediates. Employing visible-light photo-redox catalysis, primary sulfonamides are coupled with electron-deficient alkenes to efficiently and mildly construct C-C bonds. Interestingly, a divergence between intermolecular hydrogen-atom transfer (HAT) catalysis and intramolecular [1,5] HAT was observed through precise manipulation of the protecting group. This dichotomy was leveraged to achieve excellent alpha/delta site-selectivity.
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