期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 12, 页码 3928-3933出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201814366
关键词
cyclic phosphoramidite; monodisperse polyP; phosphoric anhydrides; triphosphorylation
资金
- HFSP grant (Human Frontier Science Program) [RGP0025/2016]
An iterative polyphosphorylation approach is described, which is based on a phosphoramidite (P-amidite) derived reagent (c-PyPA) obtained from the cyclization of pyrophosphate with a reactive diisopropylaminodichlorophosphine. This type of reagent is unprecedented as it represents a reactive P-amidite without protecting groups. The reagent proved to be stable in solution over several weeks Its utility is described in the context of iterative mono directional and bidirectional polyphosphorylations. The ensuing functionalized cyclotriphosphate can be opened with a variety of nucleophiles providing ready access to diverse functionalized polyphosphate chains of defined length with several tags, including both P-N and P-O labels. Their interaction with exo-and endopolyphosphatases is described.
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