期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 12, 页码 3913-3917出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201814282
关键词
analysis; bioimaging; circular polarized light; living cells; metal ions
资金
- National Natural Science Foundation of China [21874058, 21771090, 31771084, 21631005, 21673104]
- National Key RD Program [2017YFA0206902]
Here, we constnict a handedness-dependent circular polarized light (CPL)-activated chiral satellite assemblies formed from DNAzymes and spiny platinum modified with gold nanorods and upconversion nanoparticles (UCNPs), enabling the simultaneous quantitative analysis of multiple divalent metal ions in living cells. The chiral nanoprobes, in coordination with their corresponding divalent metal ions under 980 nm left circular polarized (LCP) light illumination, served as an in situ confocal bioimaging platform for the quantitation of the given intracellular metal ions. The limit of detection (LOD) of the chiral probes in living cells is 1.1 nmol/ 10(6 )cells, 1.02 nmol/10(6) cells and 0.45 nmol/10(6) cells for Zn+, Mg2+, and Cu2+, respectively.
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