期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 16, 页码 5327-5331出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900421
关键词
1,6-enynes; asymmetric catalysis; bimetallic catalysis; cycloisomerization; Diels-Alder reactions
资金
- National Natural Science Foundation of China [21890723, 21772127]
We report the combination of transition-metal-catalyzed diversified cycloisomerization of 1,6-enynes with chiral Lewis acid promoted asymmetric Diets-Alder reaction to realize asymmetric cycloisomerization/Diels-Alder relay reactions of 1,6-enynes with electron-deficient alkenes. A broad spectrum of chiral [5,6]-bicyclic products could be acquired in high yields (up to 99 %) with excellent diastereoselectivy (> 19:1 dr) and enantioselectivity (up to 99 % ee).
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