期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 19, 页码 6425-6429出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201902191
关键词
arylation; asymmetric synthesis; copper; ligand design; radicals
资金
- National Basic Research Program of China (973) [2015CB856600]
- National Nature Science Foundation of China (NFSC) [21532009, 21790330, 21821002, 21761142010]
- Science and Technology Commission of Shanghai Municipality [17XD1404500, 17QA1405200, 17JC1401200]
- strategic Priority Research Program [XDB20000000]
- Key Research Program of Frontier Science of the Chinese Academy of Sciences [QYZDJSSWSLH055]
- CAS Interdisciplinary Innovation Team
A novel enantioselective copper-catalyzed arylation of benzylic C-H bonds, using alkylarenes as a limiting reagent, has been developed. A chiral bisoxazoline ligand bearing an acetate ester moiety plays a key role in both the reactivity and enantioselectivity of the reaction. The reaction provides efficient access to various chiral 1,1-diarylalkanes in good yields with good to excellent enantioselectivities, and displays excellent functional-group tolerance.
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