期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 58, 期 19, 页码 6391-6395出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201900095
关键词
amination; bisphosphines; cross-coupling; ligand design; nickel
资金
- NSERC of Canada
- Killam Trusts
- Dalhousie University
Base-metal catalysts capable of enabling the assembly of heteroatom-dense molecules by cross-coupling of primary heteroarylamines and (hetero)aryl chlorides, while sought-after given the ubiquity of unsymmetrical di(hetero)arylamino fragments in pharmacophores, are unknown. Herein, we disclose the new double cage bisphosphine PAd2-DalPhos (L2). The derived air-stable Ni-II pre-catalyst C2 functions well at low loadings in challenging test C-N cross-couplings with established substrates, and facilitates the first Ni-catalyzed C-N cross-couplings of primary five- or six-membered ring heteroarylamines and activated (hetero)aryl chlorides, with synthetically useful scope that is competitive with Pd catalysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据