期刊
ANALYTICAL CHEMISTRY
卷 91, 期 8, 页码 5225-5234出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b05960
关键词
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资金
- National Natural Science Foundation of China [21871121, 21801104, 21601074, 21431002]
- Fundamental Research Funds for the Central Universities [Lzujbky-2018-ot01]
Real-time temperature feedback in tissue based on photothermal therapy is an urgent problem to be solved in cancer treatment. Herein, a smart all-in-one nanoprobe THA@Eu-NMOF@Fe/TA was designed and assembled by postsynthetical functionalization of an Eu(III)-based nanoscale metal-organic framework (Eu-NMOF) with a two-photon-absorbing beta-diketonate ligand 4,4,4-trifluoro-1-(9-hexylcarbazol-3-yl)-1,3-butanedione (HTHA) and Fe(III)/tannic acid assembly (Fe/TA). Such a functionalized material can simultaneously achieve the temperature-sensing and optical heating under a single beam of near infrared (NIR) light. Under 808 nm laser excitation, real-time feedback of temperature by monitoring thermoresponsive fluorescence emission ratio (I-616/I-590) and fluorescence lifetime of Eu(III) ions were realized. Meantime, Fe/TA served as the photothermal agent and antibacterial agent to implement photothermal therapy (PTT) and antibacteria simultaneously. The functions of the nanoprobe were proved with ex vivo experiments, and the antibacterial activity against Gram-positive and Gram-negative bacteria of the probe was also elaborately evaluated. Our work paves a new avenue for engineering a new cancer treatment probe which can achieve real-time temperature sensing feedback during PTT and antibacterial process.
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