期刊
ANALYTICAL CHEMISTRY
卷 91, 期 6, 页码 3795-3799出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.9b00170
关键词
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资金
- National Natural Science Foundation of China [21675080, 21405134, 21632008, 21775071]
- Natural Science Foundation of Jiangsu Province [BK20170073]
- Scientific Research Foundation of Graduate School of Nanjing University [2016CL04]
Liposomal photoelectrochemical (PEC) bioanalysis has recently emerged and exhibited great potential in sensitive biomolecular detection. Exploration of the facile and efficient route for advanced liposomal PEC bioanalysis is highly appealing. In this work, we report the split-type liposomal PEC immunoassay system consisting of sandwich immunorecognition, CdS quantum dots (QDs)-loaded liposomes (QDLL), and the release and subsequent capture of the QDs by a separated TiO2 nanotubes (NTs) electrode. The system elegantly operated upon the protein binding and lysis treatment of CdS QDLL labels within the 96-well plate, and then the CdS QDs-enabled sensitization of TiO2 NTs electrode. Exemplified by cardiac markers troponin I (cTnI) as target, the proposed system achieved efficient activation of TiO2 NTs electrode and thus the signal generation toward the split-type PEC immunoassay. This work features the first use of QDs for liposomal PEC bioanalysis and is expected to inspire more interests in the design and implementation of numerous QDs-involved liposomal PEC bioanalysis.
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