期刊
ANALYTICAL CHEMISTRY
卷 91, 期 5, 页码 3467-3474出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.8b05024
关键词
-
资金
- NSFC [51473028]
- Key Scientific and Technological Project of Jilin Province [20150204011GX, 20160307016GX]
- Development and Reform Commission of Jilin Province [20160058]
- Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences
Strongly red luminescent and water-soluble probes are very important for studying biological events and processes. Fluorescent nanoparticles (NPs) built from the aggregation-induced emission luminogen (AIEgen) and amphipathic polymeric matrixes have been considered as promising candidates for bioimaging. However, AIE NPs with long wavelength absorption suitable for in vivo application are still scarce. In this work, three AIE-active red-emissive BODIPY derivatives with long-wavelength absorption were rationally designed and synthesized. Then three NPs based on these AIEgens exhibit bright red photoluminescence with high fluorescence quantum yield in aqueous media. These NPs uniformly dispersed in water and showed excellent stability and good biocompatibility. They can be readily internalized by HeLa cells, and the staining process is performed by simply shaking the culture with cells for just a few seconds at room temperature, which indicates an ultrafast and easy-to-operate staining protocol. More importantly, long-term tracing in living cells and mouse over 15 days is successfully achieved. The strong fluorescence signals, ultrafast staining procedure, and long-term tracing abilities indicate that these AIE NPs hold great potential for monitoring biological processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据