期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
卷 181, 期 1, 页码 86-90出版社
WILEY
DOI: 10.1002/ajmg.c.31680
关键词
growth; growth hormone; Turner syndrome
资金
- National Institutes of Child Health and Development [NICHD R13 HD096857-01]
- Patient-Centered Outcomes Research Institute (PCORI) Eugene Washington PCORI Engagement Award [10460]
Short stature is the most ubiquitous feature of Turner syndrome (TS). Today, many girls with TS are treated with recombinant human growth hormone (GH) to accelerate growth in childhood and to improve adult height. Here, we will review the history of our understanding of growth in TS, reflect on the path of clinical trials ultimately leading to regulatory approval for clinical use of GH, discuss factors associated with growth outcomes and survey the current unanswered questions about growth and GH in TS.
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