期刊
AMERICAN JOURNAL OF EPIDEMIOLOGY
卷 188, 期 6, 页码 1130-1135出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwz058
关键词
cancer incidence; childhood cancer; differences by sex; leukemia; lymphomas
资金
- National Key Research and Development Program of China [2017YFC0907002, 2017YFC0907501, 2017YFC211700]
- National Natural Science Foundation of China [81772170, 81502870]
- Science and Technology Commission of Shanghai Municipality [16JC1400500]
- International S&T Cooperation Program of China [2015DFE32790]
- Shanghai Municipal Science and Technology Major Project award [2017SHZDZX01]
We investigated the differences in cancer incidence between boys and girls. The incidence data for pediatric cancers were retrieved from the International Incidence of Childhood Cancer project (1990-2015). Poisson regression was applied to detect the sex differences in cancer incidence at global and regional levels. Boys were more susceptible to childhood cancers than girls, with a global boy-to-girl incidence rate ratio of 1.27 (95% confidence interval (CI): 1.26, 1.28) for leukemia, 1.48 (95% CI: 1.46, 1.51) for lymphomas, 1.10 (95% CI: 1.08, 1.11) for central nervous system neoplasms, 1.11 (95% CI: 1.08, 1.13) for neuroblastoma, 1.05 (95% CI: 1.02, 1.09) for retinoblastoma, and 1.39 (95% CI: 1.33, 1.45) for hepatic tumors. Incidence among girls was predominant only in renal tumors (incidence rate ratio = 0.90, 95% CI: 0.88, 0.92). Significant sex differences were observed in childhood cancers based on global-scale cancer data. The most pronounced disparities were observed mostly in developing countries, highlighting that data registration quality should be improved and that attention is needed for health-care access and service utilization for girls in these regions. Additionally, given the limited exposures to environmental risk factors in children, the differences might be mainly attributable to some endogenous risk factors and warrant further investigations.
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