期刊
AMERICAN JOURNAL OF MEDICINE
卷 129, 期 7, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjmed.2016.01.037
关键词
Furosemide; Heart failure; Thiamine; Thiamine deficiency
Diuretic therapy is a cornerstone in the management of heart failure. Most studies assessing body thiamine status have reported variable degrees of thiamine deficiency in patients with heart failure, particularly those treated chronically with high doses of furosemide. Thiamine deficiency in patients with heart failure seems predominantly to be due to increased urine volume and urinary flow rate. There is also evidence that furosemide may directly inhibit thiamine uptake at the cellular level. Limited data suggest that thiamine supplementation is capable of increasing left ventricular ejection fraction and improving functional capacity in patients with heart failure and a reduced left ventricular ejection fraction who were treated with diuretics (predominantly furosemide). Therefore, it may be reasonable to provide such patients with thiamine supplementation during heart failure exacerbations. (C) 2016 Elsevier Inc. All rights reserved.
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