期刊
AGEING RESEARCH REVIEWS
卷 50, 期 -, 页码 9-18出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2019.01.003
关键词
Physical activity; Exercise; Dementia; Alzheimer's disease; Beta-amyloid; Tau
资金
- National Health and Medical Research Council Dementia Research Development Fellowship [GNT1097105]
Several prospective cohort studies have reported an association between higher levels of physical activity and decreased risk of cognitive decline and dementia, years later. To support physical activity as a preventative measure against dementia, including Alzheimer's disease (AD; the most common form of dementia), evidence regarding the underlying mechanisms is vital. Here, we review previous work examining the role of physical activity in modulating levels of AD pathological hallmarks, beta-amyloid (AD) and tau (in the brain, cerebrospinal fluid and blood). Robust evidence from transgenic animal studies suggests that physical activity (voluntary wheel running) and exercise (forced wheel running) are implicated in lowering levels of brain AD and tau. Nevertheless, evidence from human studies, utilising measurements from positron emission tomography and cerebrospinal fluid biomarkers, is less consistent. Rigorous randomised controlled trials utilising long exercise interventions are vital to further understand the relationship between physical activity and Alzheimer's disease.
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