期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 361, 期 12, 页码 2897-2903出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900176
关键词
Isoquinolin-1(2H)-ones; Rhodium; C-H activation; 1,3-Dienylation; Methylenecyclopropanes
资金
- Natural Science Foundation of Tianjin City [18JCYBJC21300]
- National Key RD Program [2017YFD0200507]
- National Natural Science Foundation of China [21372134]
Herein, we report a Rh(III)-catalyzed 1,3-dienylation of isoquinolin-1(2H)-ones through C-H activation. The present reaction enables the preparation of 3-(buta-1,3-dien-2-yl)isoquinolin-1(2H)-ones through the direct cross-coupling reaction of readily available isoquinolin-1(2H)-ones with methylenecyclopropanes, while tolerating many sensitive functional groups. Therefore, this method provides an efficient and convenient approach for modification of interesting molecules.
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