期刊
ADVANCED FUNCTIONAL MATERIALS
卷 29, 期 15, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201808646
关键词
colon cancer therapy; drug delivery system; ferulic acid; nanoparticles; paclitaxel
类别
资金
- International Cooperation and Exchange of the National Natural Science Foundation of China [51820105004]
- National Science and Technology Major Project of the Ministry of Science and Technology of China [2018ZX10301402]
- Science and Technology Program of Guangzhou [201707010094]
- Guangdong Innovative and Entrepreneurial Research Team Program [2013S086, 2016ZT06S029]
- Science and Technology Planning Project of Shenzhen [JCYJ20170307141438157]
As colorectal cancer is the fourth leading cause of cancer-related death worldwide, colorectal cancer therapy requires new strategies for improved therapeutic effects. Recently, nanodrug carriers have emerged to weaken the systemic toxicity of chemotherapy drugs and strengthen the treatment effectiveness against colorectal cancer. In this report, ferulic acid, a plant derivative, is polycondensed into poly(ferulic acid) (PFA) for the first time to serve as an excellent drug carrier with anticancer performance. PFA self-assembles into nanoparticles by nanoprecipitation, and the screened PFA nanoparticles (NPs) have a diameter of approximate to 100 nm and possess a reasonable drug-loading capacity of approximate to 8.3% of paclitaxel (PTX). Evaluation of CT26 cells and a corresponding mouse model indicates remarkable inhibition of colon cancer with PTX-loaded PFA nanoparticles (PFA@PTX NPs) treatment both in vitro and in vivo. Meanwhile, evaluation of blank PFA NPs in a tumor mouse model also shows tumor inhibition, confirming that PFA itself has an anticancer effect in vivo. Overall, the novel nanoparticles based on poly(ferulic acid) can not only effectively deliver chemodrugs but also provide additional anticancer therapeutic effects, providing a promising platform for clinical colon cancer therapy.
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